Cytoplasmic protein-tyrosine kinases (PTKs) are enzymes involved in transducing a vast number of signals in metazoans. The importance of the Tec family of kinases was immediately recognized when, in 1993, mutations in the gene encoding Bruton's tyrosine kinase (Btk) were reported to cause the human disease X-linked agammaglobulinemia (XLA).(1,2) Since then, additional kinases belonging to this family have been isolated, and the availability of full genome sequences allows identification of all members in selected species enabling phylogenetic considerations. Tec kinases are (...) endowed with Pleckstrin homology (PH) and Tec homology (TH) domains and are involved in diverse biological processes related to the control of survival and differentiation fate. Membrane translocation resulting in the activation of Tec kinases with subsequent Ca2+ release seems to be a general feature. However, nuclear translocation may also be of importance. The purpose of this essay is to characterize members of the Tec family and discuss their involvement in signaling. The three-dimensional structure, expression pattern and evolutionary aspects will also be considered. BioEssays 23:436–446, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This volume sets Berkeley's philosophy in its historical context by providing selections from: firstly, works that deeply influenced Berkeley as he formed his main doctrines; secondly, works that illuminate the philosophical climate in which those doctrines were formed; and thirdly, works that display Berkeley's subsequent philosophical influence. The first category is represented by selections from Descartes, Malebranche, Bayle, and Locke; the second category includes extracts from such thinkers as Regius, Lanion, Arnauld, Lee, and Norris; while reactions to Berkeley, both positive (...) and negative, are drawn from a wide range of thinkers - Leibniz, Baxter, Hume, Diderot, Voltaire, Reid, Kant, Herder, and Mill. (shrink)

The Bohr-Heisenberg scheme, which forms the basis of any current version of the standard or Copenhagen interpretation of quantum mechanics, is shown to be internally inconsistent. Although the inconsistencies demonstrated here are directly relatable to Einstein's opinion that it is unsatisfactory to interpret physical theory solely in terms of the knowledge gained from experimental outcomes, it is nevertheless shown that Einstein's view requires important modification. The implications of the Bohr-Heisenberg schem's self-inconsistency are discussed in relation to Bell's theorem and Aspect's (...) experiments. (shrink)

The paper reviews the current situation regarding a new theory of brain dynamics put forward by the authors in an earlier publication. Motivation for the theory is discussed in terms of two issues: the long-standing problem of accounting for the stability and nonlocal properties of memory, and the experimental and theoretical evidence against the classical theory of brain action. It is shown that the new theory provides an explanation and a conceptually unifying framework for phenomena of brain action that resist (...) classical explanation. Further independent experiments provide strong additional support for the theory. The fact that this theory incorporates quantum mechanisms in an essential way is considered to be of wide scientific interest in view of the unique status of the brain in relation to the physical, biological, and mental orders in nature. (shrink)

One of the standard ways of proving the consistency of additional hypotheses with the basic axioms of an axiom system is by the construction of what may be described as ‘inner models.’ By starting with a domain of individuals assumed to satisfy the basic axioms an inner model is constructed whose domain of individuals is a certain subset of the original individual domain. If such an inner model can be constructed which satisfies not only the basic axioms but also the (...) particular additional hypothesis under consideration, then this affords a proof that if the basic axiom system is consistent then so is the system obtained by adding to this system the new hypothesis. This method has been applied to axiom systems for set theory by many authors, including v. Neumann, Mostowski, and more recently Gödel, who has shown by this method that if the basic axioms of a certain axiomatic system of set theory are consistent then so is the system obtained by adding to these axioms a strong form of the axiom of choice and the generalised continuum hypothesis. Having been shown in this striking way the power of this method it is natural to inquire whether it has any limitations or whether by the construction of a sufficiently ingenious inner model one might hope to decide other outstanding consistency questions, such as the consistency of the negations of the axiom of choice and continuum hypothesis. In this and two following papers we prove some general theorems concerning inner models for a certain axiomatic system of set theory which lead to the result that as far as a fairly large family of inner models are concerned this method of proving consistency has been exhausted, that no essentially new consistency results can be obtained by the use of this kind of model. (shrink)

I have argued that without an adequate solution to the knower paradox Fitch's Proof is- or at least ought to be-ineffective against verificationism. Of course, in order to follow my suggestion verificationists must maintain that there is currently no adequate solution to the knower paradox, and that the paradox continues to provide prima facie evidence of inconsistent knowledge. By my lights, any glimpse at the literature on paradoxes offers strong support for the first thesis, and any honest, non-dogmatic reflection on (...) the knower paradox provides strong support for the second. Whether verificationists want to go the route I've suggested is not for me todecide. As in the previous section my aim has been that of defending the mere viability of verificationism in the face of what many, many philosophers have taken to be its death-knell, namely Fitch's Proof. But, as the final objection makes clear, showing that verificationism can live in the face of Fitch's Proof is one thing; showing that it should live is another project. If nothing else, I hope that this papershows that verificationists still have a project to pursue; Fitch's Proof, contrary to popular opinion, need not bury verificationism.13. (shrink)

J C Glass, W Johnson; Lakatosian Methodology and the Practical Implementation of a Liberal Notion of Education, Journal of Philosophy of Education, Volume 25, I.

Hume's doctrine of natural belief allows that certain beliefs are justifiably held by all men without regard to the quality of the evidence which may be produced in their favour. Examples are belief in an external world and belief in the veracity of our senses. According to R. J. Butler, Hume argues in the Dialogues that belief in God is of this sort. More recently John Hick has argued that for some people it is as natural to believe in God (...) as to believe in an external world. I shall first inquire what Hume understands by reasonable belief and by natural belief. I shall then use the results of this investigation to argue, against Butler, that belief in God is not a natural belief; and against Hick, more briefly, that his thesis is not viable in as far as it depends upon Hume's doctrine of natural belief. These discussions are important to the philosophy of religion since by means of natural beliefs it could be urged that belief in God is something justifiable without reference to reason or evidence: a position which would be of immense value to the theist. (shrink)

In this paper the squared mass of the hadron is defined as a random variable, whose average is the measured quantity. This leads to a mass formula, of a unique type for mesons and baryons, with a general law for the spin variation of the coefficients. The central squared masses form an overall geometrical scheme; in the baryon case it contains trajectories which are a fine structure of the Regge trajectories. For the accurately measured masses the difference between the computed (...) and experimental value lies within 5 MeV for mesons and baryons. The geometrical scheme will be the basis for the computation of the decay rates, to be developed in the next paper. (shrink)

In this third and last paper on inner models we consider some of the inherent limitations of the method of using inner models of the type defined in 1.2 for the proof of consistency results for the particular system of set theory under consideration. Roughly speaking this limitation may be described by saying that practically no further consistency results can be obtained by the construction of models satisfying the conditions of theorem 1.5, i.e., conditions 1.31, 1.32, 1.33, 1.51, viz.:This applies (...) in particular to the ‘complete models’ defined in 1.4. Before going on to a precise statement of these limitations we shall consider now the theorem on which they depend. This is concerned with a particular type of complete model examples of which we call “proper complete models”; they are those complete models which are essentially interior to the universe, those whose classes are sets of the universe constituting a class thereof, i.e., those for which the following proposition is true:The main theorem of this paper is that the statement that there are no models of this kind can be expressed formally in the same way as the axioms A, B, C and furthermore it can be proved that if the axiom system A, B, C is consistent then so is the system consisting of axioms A, B, C, plus this new hypothesis that there exist no proper complete models. When combined with the axiom ‘V = L’ introduced by Gödel in this new hypothesis yields a system in which any normal complete model which exists has for its universal class V, the universal class of the original system. (shrink)

A unique description of the phenomena that arise from the interaction between quantum systems and their environment. Because of the novel character of the approach discussed, the book addresses scientists from all fields of physics and related disciplines as well as students of physics.

My interest in gathering together a collection of this sort was generated by a fortuitous combination of historical studies under Professor Keith Lehrer and studies in cognitive science under Professor R. Michael Harnish at the University of Arizona. Work on the volume began there while I was an instructor in the Department of Linguistics and was greatly encouraged by participants in the Faculty Seminar on Cognitive Science chaired by Professor Lance J. Rips. I wish to express my appreciation to all (...) of these and to many other individuals with whom I discussed the possibility of contribution to this work. I am especially grateful to the authors of the essays included here, as they showed more patience than I could have hoped for in seeing me through a number of uncertain stages in development of the project. My thanks are also due to my colleague Charles Reid for assistance in reviewing submissions, to Tim McFadden for computer resources, and again, to Keith Lehrer for continuing advice in arrangements for publication. Financial support for manuscript preparation was provided in part under University Research Grant No. 617 from the University Research Council, Youngstown State University. (shrink)

Atque illo die certe Aricia rediens devertit Clodius ad se in Albanum: quod ut sciret Milo ilium Ariciae fuisse, suspicari tamen debuit eum, etiam si Romam illo die reverti vellet, ad villam suam, quae viam tangeret, deversurum.THIS passage is interesting in that its argument runs counter to the main picture which Cicero had earlier presented of the movements of Milo and Clodius before they met on the Appian Way in January 52 B.C. In an earlier passage Cicero says: ‘Interim cum (...) sciret Clodius–neque enim difficile erat id scire–xiter sollemne, legitimum, necessarium ante diem XIII Kalendas Februarias Miloni esse Lanuvium ad flaminem prodendum, quod erat dictator Lanuvii Milo, Roma subito ipse profectus pridie est, ut ante suum fundum, quod re intellectum est, Miloni insidias conlocaret.’ Cicero remains true to this latter version in all the relevant arguments concerning the motives and movements of Clodius and Milo. Milo had legitimate business at Lanuvium, and hence a legitimate reason for being on the road at the time of the affray; Clodius′ presence is explained by Cicero as due solely to the desire to place an ambush for his enemy at a convenient spot, i.e. in front of his farm, and for this reason he had set out from Rome a day before Milo, when his presence was really required in Rome. (shrink)

Private-property anarchy is better than the state in the enhancement of liberty and welfare. Strictly speaking, market exchange is one aspect of private-property anarchy. But I here focus on market-anarchy as that is a main source of confusion and debate. Similarly, pluralism is another aspect of private-property anarchy. I focus on pluralism as an example of a currently popular topic where private-property anarchy is misunderstood. ‘Pluralism’ here means ‘(tolerating) different ways of life’. ‘The market’ means ‘voluntary exchange’. ‘Anarchy’ means ‘no (...) rule’. Both interpersonal liberty and private property are inherently anarchic: no one is ruled to the extent that these exist. They are also naturally pluralist. The state, by contrast, coercively imposes ultimate control and is thus inherently illiberal and naturally Procrustean. Democratic prejudice obscures these facts. (shrink)

J C Walker; Dusting Off Educational Studies: a methodology for implementing certain proposals of John Wilson’s, Journal of Philosophy of Education, Volume 18, I.

Book Information Truth. Truth Enrique Villanueva Atascadero, CA Ridgeview Publishing Company 1997 i + 446 Edited by Enrique Villanueva . Ridgeview Publishing Company. Atascadero, CA. Pp. i + 446.

Primarily using philosophy, but also some social science, Escape from Leviathan (EfL) explains and defends what it calls an extreme version of the implicit ‘classical liberal compatibility thesis’: liberty, welfare, and anarchy are overwhelmingly complementary in normal practice (rationality is added for its intimate theoretical connections to these categories). This is done using theories, not definitions, of each concept. This important thesis is entirely positive. Therefore, somewhat unusually, all normative issues are avoided as irrelevant distractions in this context. In addition, (...) the epistemology used is also unorthodox. A justificationist, or foundationalist, approach would be literally illogical: the self-refuting trilemma faced by ‘supporting justifications’ (as regards arguments and evidence) is of entailing infinite regresses, dogmatic starting points, or circularities. Consequently, critical rationalism is assumed: conjecture and criticism are all that is possible. Thus all aspects of the conjectured thesis are explained and defended from criticism as thoroughly as the book can encompass. It is concluded that the thesis has not been refuted and so may be critically preferred. (However, this could all still be viewed as a ‘justification’ by those thus inclined.) All of this is made clear enough in the short introductory chapter and repeated where relevant throughout. Yet some reviews do not have a firm grasp of the specific project and so reject it with unsound criticisms. We now turn to one such example. (shrink)

ONE OF HUME’S ARGUMENTS IN "OF MIRACLES" CONCLUDES (A) THAT MIRACLES IN DIFFERENT RELIGIONS ARE CONTRARY FACTS, AND (B) THAT ANY MIRACLE IN FAVOR OF ONE RELIGION IS EVIDENCE AGAINST ALL OTHERS. I ARGUE THAT WHILE (A) IS ABSURD, (B) IS APPLICABLE TO CHRISTIANITY IN VIRTUE OF ITS EXCLUSIVIST CLAIMS. IT WAS ACCEPTED BY THE EARLY FATHERS AND STILL HAS TO BE ASSUMED BY ALL BUT THE MOST DIFFIDENT CHRISTIANS.

We know a lot more about the epistemology of the net at the time the present summary is being written than we did two years ago when the topic of this collaboration was decided upon. In part, this increase in knowledge is a consequence of the tremendous development of the net itself; in part, however, it is a consequence of our own series of exchanges. I would like, therefore, to say that the project had a positive outcome; but to say (...) this would be misleading. (shrink)

Private-property anarchy is better than the state in the enhancement of liberty and welfare. Strictly speaking, market exchange is one aspect of private-property anarchy. But I here focus on market-anarchy as that is a main source of confusion and debate. Similarly, pluralism is another aspect of privateproperty anarchy. I focus on pluralism as an example of a currently popular topic where private-property anarchy is misunderstood. ‘Pluralism’ here means ‘(tolerating) different ways of life’. ‘The market’ means ‘voluntary exchange’. ‘Anarchy’ means ‘no (...) rule’. Both interpersonal liberty and private property are inherently anarchic: no one is ruled to the extent that these exist. They are also naturally pluralist. The state, by contrast, coercively imposes ultimate control and is thus inherently illiberal and naturally Procrustean. Democratic prejudice obscures these facts. (shrink)

Recent debates have led some to question the legitimacy of physicians refusing to provide legally permissible services for reasons of conscience. In this paper, I will explore the question of whether medical professionals have a collective duty to ensure that their profession provides nondiscriminatory access to all medical services. I will argue that they do not. I will also argue for an approach to dealing with intractable moral disagreements between patients and physicians that gives both parties veto power with regards (...) to participation. Finally, I will respond to three objections to allowing physicians broad freedom to act on their consciences: such allowances would violate the conscience of the patient, would lead to unfairness, and would thwart important societal goals. (shrink)

THERE ARE TWO CONCEPTS OF MIRACLE: AS (A) THE VIOLATION OF A NATURAL LAW, AND AS (B) A STRIKING COINCIDENCE WITHIN NATURAL LAW. DIFFICULTIES IN (A) HAVE BEEN WIDELY DISCUSSED, E.G., BY R SWINBURNE. THOSE IN (B) HAVE NOT. I ARGUE THAT IF DIFFICULTIES IN (A) FORCE A RETREAT TO (B), THEN A PLACE MUST BE FOUND FOR A GOD TO ACT TO PRODUCE (B). SEVERAL POSSIBILITIES ARE CONSIDERED; NONE ARE FOUND SATISFACTORY EXCEPT POSSIBLY THE GOD INFLUENCING UNNOTICED AN ANIMATE (...) OBJECT. I CONCLUDE WITH A NEW AND FAVORABLE LOOK AT HUME’S CONTRARY MIRACLES ARGUMENT. (shrink)

In this paper I wish first of all to argue against two possible views about colour qualities, which I shall label the Objectivist and Subjectivist views respectively. I find these views to be prevalent among philosophers of my acquaintance, though sometimes they are hidden by a veneer of post-Wittgensteinian sophistication. Part of my argument will depend on modern scientific theories of colour vision. In the second part of the paper I shall argue for a different view of my own.

In an article in Philosophy R. G. Swinburne set out to argue that none of Hume's formal objections to the design argument ‘have any validity against a carefully articulated version of the argument’ . This, he maintained, is largely because Hume's criticisms ‘are bad criticisms of the argument in any form’ . The ensuing controversy between Swinburne and Olding 1 has focused upon the acceptable/unacceptable aspects of the dualism presupposed in Swinburne's defence of the design argument; upon whether any simplification (...) is achieved by reducing scientific explanation to agent explanation; and upon the problems which arise from taking a man's acting upon his body as the analogy for understanding a disembodied agent acting upon matter. In this article I shall refer to the Swinburne-Olding controversy when appropriate but my main concern is to return to Swinburne's original article and argue, seriatim , that Hume's individual criticisms of the design argument are for the most part a great deal more powerful than Swinburne allowed. I shall contend that cumulatively they destroy the design argument as any sort of rational foundation for theistic belief. But first I shall indicate briefly the character of the argument together with one or two of the distinctions and refinements in terms of which it has been found helpful to carry on the discussion in recent years. (shrink)

In his note [5] Hausner states a simple combinatorial principle, namely: $$(H)\left\{ {\begin{array}{*{20}c} {if f is a function a non - empty finite set \sigma into itself, p a} \\ {prime, f^p = i_\sigma and \sigma _0 the set of fixed points of f, then } \\ {\left| \sigma \right| \equiv \left| {\sigma _0 } \right|(mod p).} \\\end{array}} \right.$$ .He then shows how this principle can be used to prove:Fermat's little theorem,Cauchy's theorem for finite groups,Lucas' theorem for binomial numbers.Letε=(0,1, ...),ℱ (...) 1−1 the family of all one-to-one functions from a subset ofε intoε andℳ 1−1 the family of all p.r. (i.e., partial recursive) one-to-one functions from a subset ofε intoε. A subsetα of ε is finite, ifα is not equivalent to a proper subset under a function inℱ 1−1. The setα is calledisolated, if it is not equivalent to a proper subset under a function inℳ 1−1. An isolated set can also be defined as a subset ofε which has no infinite r.e. (i.e., recursively enumerable) subset. While every finite set is isolated, there are $c = 2^{\aleph _0 }$ infinite sets which are isolated; these sets are calledimmune. It is the purpose of this paper to generalize (H) to a principle (H*) for isolated sets and to show how (H*) can be used to prove generalizations of Fermat's little theorem and Cauchy's theorem for finite groups. We have been unable to generalize Lucas' theorem in a similar manner. (shrink)

Professor Cohen makes extensive reference to a lecture “Hypotheses relating to the brain-mind problem” which was published in Nature. He gives a succinct account of the suggestions that I put forward, and then goes on to state that they “illustrate two fallacies which are to be found in so many contributions to the study of the body-mind relationship.” Be that as it may, but Professor Cohen has chosen most unsuitable illustrations, for in both cases they are based on misunderstandings of (...) my article. (shrink)

In this paper I begin by arguing that there are significant intellectual and normative continuities between pre-Victorian hereditarianism and later Victorian eugenical ideologies. Notions of mental heredity and of the dangers of transmitting hereditary 'taints' were already serious concerns among medical practitioners and laymen in the early nineteenth century. I then show how the Victorian period witnessed an increasing tendency for these traditional concerns about hereditary transmission and the integrity of bloodlines to be projected onto the level of national health. (...) Tracing the gradual emergence of eugenical thought, I also highlight some of the more fundamental social, political and intellectual factors that promoted this predilection for extrapolating from the individual lineage to the nation and race. In doing so I argue that fully fledged eugenical thought was always unlikely to emerge prior to the early Victorian period. However, I am also able to show that Francis Galton's 1865 eugenical proposals were far from innovative and that identifying him as the 'father' of the eugenics movement is highly misleading. (shrink)

In the recent past, several papers have pointed to the possibility that tumour removal generates a permissive environment in which tumour growth is potentiated. This phenomenon has been coined “perioperative tumour growth” and whilst it represents a departure in terms of our attitude to the surgical process, this concept was first hinted at by Paget1Sir James Paget (1814–1899) was a surgeon and physiologist who is widely held (along with Rudolph Virchow) to be the father of the science of pathology. Paget (...) described Paget's disease of the nipple as well as Paget's disease of bone. himself. Despite this, the time interval immediately before and after cancer surgery (i.e. the perioperative period) remains an underutilised interval during which chemotherapeutic regimens are rarely implemented. Herein, we present a summarised review of the literature that supports the concept that tumour removal may potentiate the growth of residual neoplastic disease. We also outline current knowledge regarding underlying mechanisms and in this manner highlight potential therapeutic entry points. Finally, we emphasise the urgent need for trials of agents that could protect patients against the harmful host–tumour interactions that may occur during the perioperative period. BioEssays 28: 433–437, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

A vast amount has been written on the relationship between Terence's and Menander's Eunuchus. On some points a good measure of agreement has been reached, but much remains in dispute. In an important article W. Ludwig convincingly demonstrated the inner unity of Terence's plot, against earlier theories of large-scale ‘contaminatio’ The nature of the changes made by Terence in introducing two characters from Menander's Colax is now fairly clear, although argument is possible over details. The changes are numerous but relatively (...) small and do not affect the main lines of Menander's plot. In this paper I shall argue that Terence made similar changes in two other parts of the play, and that these caused certain anomalies which have prompted theories of more drastic Terentian change. (shrink)